| Palacio de Villapanés | Sevilla | Andalucía | Key | — | Independent |
| Marbella Club Hotel | Marbella | Andalucía | 2 Keys | 115 | Grupo Marbella Club |
| Torre del Marqués Hotel Spa & Winery | Monroyo | Aragón | 3 Keys | 18 | Small Luxury Hotels |
| Canfranc Estación, a Royal Hideaway Hotel | Canfranc-Estación | Aragón | 2 Keys | 104 | Barceló / Royal Hideaway |
| La Torre del Visco | Fuentespalda | Aragón | Key | — | Independent |
| Cap Rocat | Cala Blava | Illes Balears | 2 Keys | 30 | Independent |
| Torralbenc | Cala en Porter | Illes Balears | Key | — | Independent |
| Cap Menorca Relais & Châteaux | Menorca | Illes Balears | Key | 17 | Relais & Châteaux |
| Cristine Bedfor | Maó / Mahón | Illes Balears | Key | — | Independent |
| Fontsanta Thermal Spa & Wellness | Campos | Illes Balears | Key | — | Independent |
| Belmond La Residencia | Deià | Illes Balears | 2 Keys | 67 | Belmond / LVMH |
| Hotel Puntagrande | Frontera, El Hierro | Canarias | Key | 4 | Independent |
| Abadía Retuerta LeDomaine | Sardón de Duero | Castilla y León | 3 Keys | 30 | Independent |
| Castillo del Buen Amor | Topas | Castilla y León | Key | — | Independent |
| Casa Grande de Gredos | Ávila | Castilla y León | Key | — | Independent |
| Convento de Belmonte | Belmonte | Castilla-La Mancha | Key | — | Independent |
| Hotel La Caminera Club de Campo | Torrenueva | Castilla-La Mancha | Key | — | Independent |
| Terra Dominicata – Hotel & Winery | Escaladei | Cataluña | 3 Keys | 26 | Independent |
| Mandarin Oriental Barcelona | Barcelona | Cataluña | 2 Keys | 120 | Mandarin Oriental |
| Masía Miró | — | Cataluña | Key | — | Independent |
| Hotel Esperit Roca | Girona | Cataluña | Key | — | Independent |
| Atrio Restaurante Hotel | Cáceres | Extremadura | 3 Keys | 14 | Independent |
| Casa Beatnik | A Coruña | Galicia | 2 Keys | 13 | Independent |
| Pepe Vieira restaurant & Hotel | Poio | Galicia | 2 Keys | — | Independent |
| Mandarin Oriental Ritz, Madrid | Madrid | Comunidad de Madrid | 3 Keys | 100 | Mandarin Oriental |
| The Westin Palace, Madrid | Madrid | Comunidad de Madrid | Key | 467 | Marriott / Westin |
| Brach Madrid | Madrid | Comunidad de Madrid | Key | 57 | Evok Collection |
| Rosewood Villa Magna | Madrid | Comunidad de Madrid | 2 Keys | 154 | Rosewood |
| Santo Mauro, a Luxury Collection Hotel | Madrid | Comunidad de Madrid | Key | 49 | Marriott / Luxury Collection |
| Aire de Bardenas | Tudela | Comunidad Foral de Navarra | Key | — | Independent |
| Akelarre | Donostia / San Sebastián | País Vasco | Key | 22 | Independent |
| The Artist Grand Hotel | Bilbao | País Vasco | Key | — | Independent |
| Hotel María Cristina, a Luxury Collection Hotel | Donostia / San Sebastián | País Vasco | Key | 136 | Marriott / Luxury Collection |